A fun quiz for wannabe Sinclair Method experts.
Who wrote The Cure for Alcoholism?
William Griffith Wilson
In 1968 David Sinclair discovered that certain people were strongly motivated to drink alcohol because...
...They were just selfish hedonists who really liked "the buzz" that they got from drinking.
...They were just really sad.
...They had a spiritual illness.
...They felt a need to relieve a physiological hunger caused by the Alcohol Deprivation Effect (ADE).
Naltrexone and nalmefene work by blocking...
...The endogenous opioidergic (endorphin) system.
...The dopaminergic system.
...The GABA system.
...The Sony PlayStation system.
The "golden rule" for success with The Sinclair Method is:
To take the pill every morning of every day for the rest of your natural life.
To always take the pill one hour before drinking every time that you do drink, but never on any days that you don't drink.
To take the pill one hour before drinking during the weekdays, but drink without it on weekends when you want to let your hair down.
Claudia Christian's 2014 documentary about The Sinclair Method was called:
One Little Pill.
Though naloxone was used in Sinclair's animal trials with specially bred rats, nalmefene and naltrexone (naloxone's sister drugs) were used in the human trials because:
Both naltrexone and nalmefene are preferable to naloxone for the purpose of treating alcohol addiction in humans because they both have a longer half-life than naloxone and are thus much better suited to a human being's metabolism.
Because naltrexone and nalmefene have less side effects than naloxone.
Ultimately, Sinclair's theory of reinforcement ("learning") and extinction ("unlearning") when it applies to alcohol addiction owes a debt to the research of:
B. F. Skinner.
In the foreword for The Cure for Alcoholism, David Sinclair describes the traditional treatment method for alcohol addiction as:
The "D method" - which involves the steps detect, delay, detox, detain, don't drink, denigrate, disulfiram, dollars and finally "do it all over again".
Bloomin' marvellous; he didn't have a single negative word to say about it!
According to page 44 of The Cure for Alcoholism, opioid antagonists such as naltrexone and nalmefene should not generally be prescribed with abstinence because:
Taking the pill without alcohol in your system makes you feel dizzy for some reason.
Naltrexone/nalmefene combined with abstinence has no curative effect. Also, opioid receptor upregulation occurs when a person stops taking the pill, consequently causing a person to be super-sensitive to endorphins should they resume their drinking without the protection of the pill.
Though naloxone has not been used to treat alcohol addiction (not for humans, anyway - see above), Sinclair had used a naloxone nasal spray in his research to successfully treat:
Bad foot odour.
Binge eating disorder (BED).